The duration of inhalation in all patients was 60 min. Methods: After receiving informed consent, 10 healthy volunteers had their blood drawn twice: before xenon inhalation (xenon - 30 vol.%, oxygen - no more than 40 vol.%, the rest - nitrogen) and immediately after. Introduction: The aim of the study was to evaluate the effect of xenon on the activation of human neutrophils in ex vivo conditions. Kuzovlev Federal research and clinical center of intensive care medicine and rehabilitology, Moscow, Russian Federation 8.4, p = 0.024, respectively).Ĭonclusions: AGTR1 rs275651 AA genotype associates with survival advantage in sepsis patients in ICU setting presumably because of contribution to lower multiorgan failure and decreased occurrence of septic shock.Įffects of xenon on proinflammatory activation and apoptosis of human neutrophils (ex vivo study) R. Expectedly SOFA values on day 2 and middle day in ICU were significantly lower in patients AGTR1 AA genotype compared to T carriers of (6.8 vs. SOFA values on days 1 were not different in patients of distinct AGTR1 genotypes. Also, patients with more common genotype AA and with sepsis often survived (p = 0.039, Fisher`s exact test, Fig. Results: Septic shock occurred more frequently in patients with AT or TT genotype, than in homozygotic carriers of AGTRI A (p = 0.01, Fisher's exact test). AGTR1 rs275651 polymorphism was studied by using specific polynucleotide tetraprimer set to amplify gene fragments from each patient’s DNA followed by analysis of PCR products in a 2% agarose gel electrophoresis. 60% of patients underwent surgery, and 42% were diagnosed with diabetes as a major comorbidity.
Methods: Study cohort included 145 ICU patients diagnosed with sepsis. So, the aim of our study was to define the contribution of AGTR1 rs275651 genotypes to the course and outcomes of critical illness, complicated with sepsis. AGTR1 rs275651 AA genotype is associated with unstable angina. The AGTR1 gene encodes angiotensin II receptor type 1, which is involved in cardiovascular diseases. Angiotensin II receptor type 1 (AGTR1) affects the condition of the vessel wall and arteriolar tone. Dysregulation of blood pressure makes a significant contribution during sepsis, especially septic shock.
Introduction: International studies demonstrate an annual increase in the frequency and impact of sepsis in intensive care units (ICU). Negovsky’ Research Institute of General Reanimatology, Moscow, Russian Federation Grigoryev Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. AGTR1 rs275651 AA genotype links with better survival in sepsis patients in ICU A.
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